Aklief

Galderma

Description

Aklief cream contains 50 micrograms (mcg/g) (w/w) trifarotene, which is a chemically stable, terphenyl acid derivative with retinoid-like activity. It is a potent RARγ agonist (retinoid acid receptor γ agonist), characterized by its high specificity to this receptor over RARα & RARβ (50- and 8-fold, respectively, with no Retinoid X Receptor (RXR) activity). In addition, trifarotene modulates retinoid target genes (differentiation and inflammatory processes) in immortalized keratinocytes and reconstructed epidermis.